Levocetirizine dihydrochloride CAS# 130018-87-0

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• Chemical Name:  Levocetirizine dihydrochloride
• CAS No.:     130018-87-0
• Molecular Fomula: ：C21H27Cl3N2O3
• Molecular weight：461.81
• Appearance: white powder
• Sample：Available

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Basic Info of hydrochloride

Basic Info
Numbering system
Properties
Safety Info
Basic Info

Numbering system

Properties

Safety Info

What is Levocetirizine dihydrochloride?

• With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Levocetirizine dihydrochloride   which has developed particularly rapidly in recent years. Do you know about Levocetirizine dihydrochloride?
• The official answer：Levocetirizine hydrochloride, the R-isomer of cetirizine hydrochloride, is a new generation of highly effective non-sedating antihistamine, with an affinity for H1 receptors twice that of cetirizine hydrochloride and an effective dose 1/2 that of cetirizine hydrochloride, with clinical results showing more advantages than loratadine ibastatin imipramine and fexofenadine. Levocetirizine retains the rapid onset of action, safety, and efficacy of cetirizine, and is reduced in dosage to 5 mg/day. In vitro and in vivo tests have shown that levocetirizine has better histamine antagonism and also inhibits the release of a variety of inflammatory mediators associated with metabolic reactions, as well as having a broader anti-inflammatory effect. Levocetirizine hydrochloride is a new generation of H1 receptor antagonist introduced in the early 21st century, which has shown potent antihistamine activity both pharmacologically and clinically, with long-lasting clinical efficacy and good safety, and is a more ideal antihistamine.

What’s the application of Levocetirizine dihydrochloride?

• It is used for the treatment of allergic diseases of the respiratory system, skin, and eyes, such as allergic rhinoconjunctivitis, allergic skin disease, allergic asthma, etc. It has the advantages of fast onset of action, strong and long-lasting effects, and few side effects. levocetirizine hydrochloride is the levorotatory R-enantiomer of cetirizine hydrochloride, which is a new generation of highly effective non-sedating antihistamine, and is the active ingredient of cetirizine, with a high degree of It is highly selective for H1 receptors (K1 = 3.2 nmol/L) and 2 times more selective than cetirizine (K1 = 6.3 nmol/L), and competitively antagonizes H1 receptors. It has no significant anticholinergic and anti-5-hydroxytryptamine effects and has a small central inhibitory effect. It can effectively inhibit the accumulation of eosinophils and inhibit allergen-induced eosinophil wandering and chemotaxis and is an efficient and highly selective peripheral H1 receptor antagonist, and in vitro and in vivo tests have shown that it has a good antihistamine effect, and also has an anti-inflammatory effect by inhibiting the release of inflammatory mediators associated with allergic reactions.

Conclusion

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