PAGOCLONE CAS# 133737-32-3

AGOCLONE, Promotion Season Now in Store and Free Sample for Testing with Factory Price

• Chemical Name:  PAGOCLONE
• CAS No.:     133737-32-3
• Molecular Fomula: ：C23H22ClN3O2
• Molecular weight：407.89
• Appearance: white powder
• Sample：Available

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Description of AGOCLONE

• AGOCLONE is an anxiolytic drug from the cyclopyrrolone family, related to better-known drugs such as the sleeping medication zopiclone. It was synthesized by a French team working for Rhone-Poulenc & Rorer S.A. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures.
  AGOCLONE was originally developed as an anti-anxiety drug, but never commercialised. It is a partial agonist acting at GABAA receptors in the brain. In contrast to zopiclone, AGOCLONE produces anxiolytic effects with little or no sedative or amnestic actions at low doses. This is because AGOCLONE is a subtype-selective drug which binds primarily to the α2/α3 subtypes of the GABAA receptor which are responsible for the anti-anxiety effects of drugs of this kind, but has relatively little efficacy at the α1 subtype which produces the sedative and memory loss effects.
  Prof. David Nutt has suggested AGOCLONE as a possible base from which to make a better social drug, as it produces the positive effects of alcohol, such as relaxation and sociability, but without also causing the negative effects like aggression, amnesia, nausea, loss of coordination and liver damage. Its effect can be quickly reversed by the action of flumazenil, which is already used as an antidote to benzodiazepine overdose.
  Nutt has published studies praising the potential of AGOCLONE which were financed by Indevus which holds the patents to the pharmaceutical and is, as of Spring 2006, seeking funding for a possible production of the compound. The significance of this is undetermined, but the long-term safety of AGOCLONE has not been assessed. The abuse potential of AGOCLONE has been assessed as being similar to, or slightly less than that of diazepam and it would also be expected to be somewhat safer due to its relatively weaker sedative effects, but development of AGOCLONE as a commercial drug would still be unlikely due to concerns about abuse.
  AGOCLONE is also being trialed as a drug to improve a stammerer’s speech fluency.

Basic Info of AGOCLONE

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What is PAGOCLONE?

• With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is PAGOCLONE   which has developed particularly rapidly in recent years. Do you know about PAGOCLONE?
• The official answer：Palone is a chemical substance with a boiling point of 582.1±50.0 °C (Predicted) Density 1.273±0.06 g/cm3 (Predicted) Acidity coefficient (pKa) 1.62±0.30 (Predicted)

What’s the application of PAGOCLONE?

• Palone is a chemical substance. Palone is a specific aminobutyric acid γ-aminobutyric acid receptor modulating drug that reduces stuttering. Palone is a new type of cyclopyrrolone that acts as a partial GABA(A) receptor agonist.

Conclusion

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