N,N-dimethyl-3, Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Chemical Name: Dapoxetine hydrochloride
- CAS No.: 129938-20-1
- Molecular Fomula: ：C21H23NO·HCl
- Molecular weight：341.88
- Appearance: White powder
- Sample：Available
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Description of N,N-dimethyl-3
- Dapoxetine, marketed as Priligy and Westoxetin, among and other brands, is the first compound developed specially for the treatment of premature ejaculation (PE) in men 18–64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, and as a consequence promoting ejaculatory delay. As a member of selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.
Originally created by Eli Lilly pharmaceutical company, dapoxetine was sold to Johnson & Johnson in 2003 and submitted as a New Drug Application to the Food and Drug Administration (FDA) for the treatment of PE in 2004. Dapoxetine has been sold in several European and Asian countries, and lately in Mexico. In the US, dapoxetine has been stuck in phase III development since 2003. However, it is expected to be marketed soon. In 2012, Menarini acquired the rights to commercialise Priligy in Europe, most of Asia, Africa, Latin America and the Middle East.
Basic Info of N,N-dimethyl-3
Basic Info
Numbering system
Properties
Safety Info
Basic Info
| Chemical Name | Dapoxetine Hydrochloride |
| Synonyms | (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine,hydrochloride;(S)-N,N-Dimethyl-α-[2-(1-naphthyloxy)ethyl]benzylamine Hydrochloride;(S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenylpropylamine Hydrochloride;Dapoxetine HCl;(S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine hydrochloride; |
| CAS No. | 129938-20-1 |
| Molecular Formula | C21H24ClNO |
| Molecular Weight | 341.87400 |
| PSA | 12.47000 |
| LogP | 5.71360 |
Numbering system
| MDL number | MFCD08272809 |
Properties
| Appearance & Physical State | White to off-white crystalline solid |
| Boiling Point | 454.4ºC at 760 mmHg |
| Melting Point | 175-179ºC |
| Flash Point | 132.6ºC |
| Vapor Pressure | 1.27E-09mmHg at 25°C |
Safety Info
| HS Code | 2922199090 |
| Symbol | GHS07 |
| Caution Statement | P305 + P351 + P338 |
| Signal Word | Warning |
| Hazard Declaration | H302; H319; H413 |
What is Dapoxetine hydrochloride?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Dapoxetine hydrochloride which has developed particularly rapidly in recent years. Do you know about Dapoxetine hydrochloride?
- The official answer：Dapoxetine hydrochloride is a white to off-white powder; it is soluble in methanol and ethanol, slightly soluble in dichloroethane, and almost insoluble in water. Dapoxetine hydrochloride is a BCSII compound, and poor solubility is a key factor affecting the difference in clinical efficacy. Dapoxetine hydrochloride exists in various crystalline forms, and the solubility of different crystalline forms varies greatly, and there is a phenomenon of phase and transformation between crystalline forms.
What’s the application of Dapoxetine hydrochloride?
- Dapoxetine hydrochloride is chemically known as (S)-N, N-dimethyl-3-(naphthalene-1-acyloxy)-phenylpropanolamine hydrochloride. Dapoxetine hydrochloride has similar pharmacological effects to other SSRIs. Initially, dapoxetine was studied for antidepressant use, but unlike other SSRIs, dapoxetine pharmacokinetics showed rapid oral absorption, short half-life, and rapid excretion, making it suitable for on-demand administration for the treatment of premature ejaculation Dapoxetine hydrochloride is a selective 5-hydroxytryptamine reuptake inhibitor (SSRI). Applications Dapoxetine impurities are organic synthesis intermediates and pharmaceutical intermediates, which can be used in laboratory research and development processes and in chemical and pharmaceutical synthesis processes, mainly as intermediates of the API dapoxetine hydrochloride.
Conclusion
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