6-Pyridinedicarboxylic acid CAS#499-83-2

6-DICARBOXYLIC, Promotion Season Now in Store and Free Sample for Testing with Factory Price

• Chemical Name:  6-Pyridinedicarboxylic acid
• CAS No.:    499-83-2
• Molecular Fomula: C7H5NO4
• Molecular weight：167.12
• Appearance:Needle-like crystals
• Sample：Available

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Description of 6-DICARBOXYLIC

• Dipicolinic acid (pyridine-2,6-dicarboxylic acid or PDC and DPA) is a chemical compound which composes 5% to 15% of the dry weight of bacterial spores. It is implicated as responsible for the heat resistance of the endospore.
  However, mutants resistant to heat but lacking dipicolinic acid have been isolated, suggesting other mechanisms contributing to heat resistance are at work.
  Dipicolinic acid forms a complex with calcium ions within the endospore core. This complex binds free water molecules, causing dehydration of the spore. As a result, the heat resistance of macromolecules within the core increases. The calcium-dipicolinic acid complex also functions to protect DNA from heat denaturation by inserting itself between the nucleobases, thereby increasing the stability of DNA.
  Two genera of bacterial pathogens are known to produce endospores: the aerobic Bacillus and anaerobic Clostridium.
  The high concentration of DPA in and specificity to bacterial endospores has long made it a prime target in analytical methods for the detection and measurement of bacterial endospores. A particularly important development in this area was the demonstration by Rosen et al. of an assay for DPA based on photoluminescence in the presence of terbium, though ironically this phenomenon was first investigated for using DPA in an assay for terbium by Barela and Sherry. Extensive subsequent work by numerous scientists has elaborated on and further developed this approach.
  It is also used to prepare dipicolinato ligated lanthanide and transition metal complexes for ion chromatography.

Basic Info of 6-DICARBOXYLIC

Basic Info
Numbering system
Properties
Safety Info
Basic Info

Numbering system

Properties

Safety Info

What is 6-Pyridinedicarboxylic acid ?

• With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is  6-Pyridinedicarboxylic acid   which has developed particularly rapidly in recent years. Do you know about  6-Pyridinedicarboxylic acid?
• The official answer：Pyridine-2,6-dicarboxylic acid is an important intermediate for pharmaceutical synthesis and has a wide range of uses. Pyridine-2,6-dicarboxylic acid is naturally present in bacterial spores, but the amount is too small to meet the demand and not easy to extract. Not conducive to industrial production and application, the earliest synthetic literature reported in 1935, ALVIN.W.Singer and S.M.MCELVAIN of the University of Wisconsin used potassium permanganate to oxidize 2,6-dimethylpyridine under the condition of the water as a solvent, with a yield of 64%. It is generally prepared industrially by oxidation of 2,6-dimethylpyridine.

What’s the application of 6-Pyridinedicarboxylic acid ?

• Use as a competitive inhibitor of bovine liver glutamate dehydrogenase Use in the preparation of ligand complexes of picolinate lanthanum as well as transition metals.

Conclusion

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