Trifluoroacetic acid CAS# 76-05-1

Trifluoroacetic acid, Promotion Season Now in Store and Free Sample for Testing with Factory Price

• Chemical Name: Trifluoroacetic acid
• CAS No.: 76-05-1
• Molecular Formula: C2HF3O2
• Molecular weight: 114.02
• Appearance: clear liquid
• Sample: Available

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Description of Trifluoroacetic acid

TFA is an organofluorine compound with the chemical formula CF3CO2H. It is a colorless liquid with a sharp odor similar to vinegar, but stronger in acidity. TFA is an analog of acetic acid with the three hydrogen atoms replaced by three fluorine atoms. The acidity of TFA is approximately 34,000 times stronger than that of acetic acid due to the electronegativity of the trifluoromethyl group. TFA is widely used in organic chemistry for various purposes.

Basic Info of Trifluoroacetic acid

Basic Info
Numbering system
Properties
Safety Info
Basic Info

Numbering system

Properties

Safety Info

What is Trifluoroacetic acid?

With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Trifluoroacetic acid which has developed particularly rapidly in recent years. Do you know about Trifluoroacetic acid?

The official answer: Trifluoroacetic acid, with the chemical formula CF3COOH and molecular weight of 114.02, can dissolve proteins if used in combination with carbon disulfide. It is also an excellent solvent for organic reactions and can obtain results that are difficult to obtain in normal solvents, for example, when quinoline is catalytically hydrogenated in normal solvents, the pyridine ring is hydrogenated preferentially, but in TFA, the benzene ring is hydrogenated preferentially. Trifluoroacetic acid decomposes to fluoroform and carbon dioxide in the presence of aniline. Enrichment of trifluoroacetic acid in immobile surface water affects agricultural and aquatic systems.

What’s the application of Trifluoroacetic acid?

It is mainly used in the production of new pesticides, pharmaceuticals, dyestuffs, etc. It also has greater potential for application development in the fields of materials, solvents, etc. TFA is mainly used in the synthesis of a variety of herbicides containing trifluoromethyl and heterocyclic, and at present, a variety of new herbicides with pyridine and quinoline groups can be synthesized.

As an extremely strong protonic acid, it is widely used as a catalyst for alkylation, acylation, and olefin polymerization of aromatic compounds; as a solvent, trifluoroacetic acid is an excellent solvent for fluorination, nitration, and halogenation reactions, especially for its derivative trifluoroacetyl’s excellent protective effect on hydroxyl and amino groups, which has very important applications in the synthesis of amino acids and peptide compounds and is used to remove the test-butoxy carbonyl (t-boc) protecting group of amino acids in peptide synthesis.

TFA is a raw material and modifier for the preparation of ionic membranes, which can significantly improve the current efficiency of the caustic soda industry and extend the service life of membranes.

TFA can also be used to synthesize trifluoroethanol, trifluoroacetaldehyde, and trifluoroacetanhydride. Mercury trifluoroacetic acid can mercurialize (electrophilic substitution) fluorobenzene at room temperature, and also convert hydrazone into diazo compounds. The lead salt of this acid converts aromatic hydrocarbons to phenols. The use of trifluoroacetic acid (TFA) as an ion-pairing reagent is common in experiments for the separation of peptides and proteins by reversed-phase chromatography. TFA in the mobile phase improves peak shape and overcomes peak spreading and tailing problems by interacting with hydrophobically bonded phases and residual polar surfaces in a variety of modes. Trifluoroacetic acid is superior to other ionic modifiers because it is readily volatile and can be easily removed from the prepared sample. On the other hand, the UV maximum absorption peak of trifluoroacetic acid is below 200 nm, which has little interference with the detection of peptides at lower wavelengths.

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