Tauroursodeoxycholic acid CAS# 14605-22-2

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• Chemical Name:  Tauroursodeoxycholic acid
• CAS No.:     14605-22-2
• Molecular Fomula: ：C26H45NO6S
• Molecular weight：499.7
• Appearance: white powder
• Sample：Available

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Description of TUDCA Soduim Salt

• Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid. It is the taurine conjugate form of ursodeoxycholic acid (UDCA). Humans are found to have trace amounts of TUDCA. However, bears contain large amounts of TUDCA in their bile; UDCA and conjugates comprise about 47% of the bile in American black bears and up to 76% in Asiatic bears. TUDCA has been used in ancient Asian pharmacopoeias for its supposed beneficial effects. UDCA is produced in several countries for the treatment of gallstones and liver cirrhosis. It is not approved by the Food and Drug Administration, in the U.S. while UDCA is approved in the United States for the treatment of primary biliary cirrhosis Ongoing research is finding TUDCA has diminishing apoptotic effects, helping with cardiac function, Huntington’s disease, Parkinson’s Disease, and stroke. Recently, TUDCA has been found to have protective effects in the eye, especially concerning retinal degenerative disorders.

Basic Info of TUDCA Soduim Salt

Basic Info
Numbering system
Properties
Safety Info
Basic Info

Numbering system

Properties

Safety Info

What is Tauroursodeoxycholic acid ?

• With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is 1-Dodecanethiol which has developed particularly rapidly in recent years. Do you know about 1-Dodecanethiol?
• The official answer: n-Dodecanethiol, also known as lauryl mercaptan; dodecanethiol, is a colorless, water-white, or light yellow liquid with a slight odor. It is mainly used as a polymerization regulator for synthetic rubber, synthetic fiber, and synthetic resin; it is also used in the production of PVC stabilizers, drugs, insecticides, fungicides, decontaminants, surface hydrophobic modifiers, etc.

What’s the application of Tauroursodeoxycholic acid ?

• It can be synthesized in the laboratory by the following method. A mixture of 125 g of bromododecane, 38 g of thiourea, and 250 ml of 95% ethanol is refluxed for 3 h. A solution of 30 g of sodium hydroxide and 300 ml of water is added and the mixture is refluxed for another 2 h. The fractionated oil layer is the crude thiol, and the aqueous layer is acidified and extracted with benzene. The extract was combined with crude thiol, washed with water, dried with anhydrous sodium sulfate, and distilled under reduced pressure after evaporation of benzene, and the product was collected as 165-169°C (5.19 kPa) fraction. About 80-84g was obtained with a yield of about 80%. It is used as polymerization regulator of synthetic rubber, synthetic fiber, and synthetic resin; also used in the production of PVC stabilizer, drug, insecticide, fungicide, and decontaminant; used in rubber, plastic, and pharmaceutical industry; used as a relative molecular mass regulator of polymer compound; used as a modifier of hydrophobic surface.

Conclusion

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