Rasagiline mesylate CAS# 161735-79-1

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• Chemical Name:  Rasagiline mesylate
• CAS No.:     161735-79-1
• Molecular Fomula: ：C13H17NO3S
• Molecular weight：267.34398
• Appearance: white powder
• Sample：Available

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Description of Agilect

Rasagiline is a selective irreversible MAO-B inhibitor. Rasagiline is an Antiparkinsonian agent.

Basic Info of Agilect

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Basic Info

Numbering system

Properties

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What is Rasagiline mesylate?

• With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Rasagiline mesylate   which has developed particularly rapidly in recent years. Do you know about Rasagiline mesylate?
• The official answer：Rasagiline mesylate was developed by Teva Pharmaceutical Industries, Israel, and was first approved for marketing by the European Medicines Agency (EMA) on February 21, 2005, and by the U.S. Food and Drug Administration (FDA) on May 16, 2006. It is indicated for monotherapy (without levodopa) in patients with primary Parkinson’s disease and as an adjunct to levodopa in Parkinson’s patients with end-of-dose fluctuations. Rasagiline mesylate is an irreversible monoamine oxidase inhibitor that reduces the breakdown of dopamine through selective inhibition of monoamine oxidase and elevates extracellular levels of dopamine in the high stratum of the brain, and the elevated dopamine levels reduce the symptoms of Parkinson’s disease. Rasagiline mesylate is 5-10 times stronger than selegiline (a first-generation monoamine oxidase inhibitor, including Sigfrancine, Midolpir, and Goldspine), and also has an improvement effect on patients who experience a decline in the efficacy of long-term dopamine preparations. In addition, the metabolite of Rexagiline is an inactive non-amphetamine substance with few side effects. More importantly, unlike other anti-Parkinsonian drugs, rasagiline mesylate also has neuroprotective effects. When combined, it can optimize levodopa treatment effects to further effectively control symptoms and reduce motor complications. According to 2017 US IMS data, the anti-Parkinson’s treatment market was $2.056 billion in the global top 500 best-selling drug market, an increase of 3.73% from the previous year.

What’s the application of Rasagiline mesylate?

• The pharmacological mechanism of Rexagiline: Rexagiline is a potent, highly selective, irreversible monoamine oxidase-B inhibitor that inhibits dopamine degradation, increases dopamine accumulation, promotes dopamine release, and improves clinical symptoms in PD patients. It has a novel chemical structure, and the novel chemical structure is intended to improve the deficiencies of the initial generation MAO-B inhibitor therapy. Slesagiline is a first-generation MAO-B inhibitor, and its metabolites include amphetamine derivatives that can cause adverse effects, such as affecting patients’ sleep. The metabolites of rasagiline, on the other hand, do not contain amphetamine derivatives. In vitro studies have confirmed that the metabolite of rasagiline, amino in an, has neuroprotective effects.

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