Tildenafil, Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Chemical Name: Tadalafil
- CAS No.: 171596-29-5
- Molecular Fomula: :C22H19N3O4
- Molecular weight:389.4
- Appearance: white powder
- Sample:Available
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Description of Tildenafil
- Tadalafil is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis, and under the name Adcirca for the treatment of pulmonary arterial hypertension. In October 2011 the U.S. Food and Drug Administration (FDA) approved Cialis for treating the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction (ED) when the conditions coincide. It initially was developed by the biotechnology company ICOS, and then again developed and marketed world-wide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Cialis tablets, in 2.5mg, 5mg, 10mg, and 20mg doses, are yellow, film-coated, and almond-shaped. The approved dose for pulmonary arterial hypertension is 40mg (two 20-mg tablets) once daily.
Tadalafil is also manufactured and sold under the name of Tadacip by the Indian pharmaceutical company Cipla in doses of 10mg and 20mg.
On November 21, 2003 the FDA approved tadalafil (as Cialis) for sale in the United States as the third ED prescription drug pill (after sildenafil citrate (Viagra) and vardenafil Hydrochloride (Levitra)). Like sildenafil and vardenafil, tadalafil is recommended as an ‘as needed’ medication. Cialis is the only one of the three that is also offered as a once-daily medication.
Moreover, tadalafil was approved in May 2009 in the United States for the treatment of pulmonary arterial hypertension and is under regulatory review in other regions for this condition. In late November 2008, Eli Lilly sold the exclusive rights to commercialize tadalafil for pulmonary arterial hypertension in the United States to United Therapeutics for an upfront payment of $150 million.
Basic Info of Tildenafil
Basic Info
Numbering system
Properties
Basic Info
Chemical Name | Tildenafil |
Synonyms | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1′,2′:1,6] pyrido[3,4-b]indole-1,4-dione;Cialis;(6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a tetrahydropyrazino [1′,2′:1,6] pyrido[3,4b] indole1,4(6H,7H)-dione; |
CAS No. | 171596-29-5 |
Molecular Formula | C22H19N3O4 |
Molecular Weight | 389.40400 |
PSA | 74.87000 |
LogP | 2.08710 |
Numbering system
MDL number | MFCD07771966 |
Properties
Appearance & Physical State | Off-White Cyrstalline Solid |
Density | 1.51 g/cm3 |
Boiling Point | 679.1ºC at 760 mmHg |
Melting Point | 298-300ºC |
Flash Point | 364.5ºC |
Refractive Index | 1.705 |
Vapor Pressure | 5.29E-13mmHg at 25°C |
What is Tadalafil ?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Tadalafil which has developed particularly rapidly in recent years. Do you know about Tadalafil?
- The official answer:Tadalafil, with a molecular formula of C22H19N3O4 and a molecular weight of 389.4, has been widely used for the treatment of male erectile dysfunction since 2003 under the trade name Cialis. Tadanafil was introduced in 2003 as a treatment for ED, with an onset of action 30 min after administration, but its optimal effect is 2 h after onset, with a sustained effect for 36 h, and its efficacy is not affected by food. Tadanafil is administered in doses of 10 or 20 mg, with a recommended initial dose of 10 mg and dose adjustments based on patient response and adverse effects. Pre-marketing studies have shown 67% and 81% efficacy after 12 weeks of oral administration of 10 or 20 mg of tadalafil, respectively. Many studies have shown that tadalafil has good efficacy in the treatment of ED.
What’s the application of Tadalafil ?
Phosphodiesterase 5 inhibitor, for the treatment of male erectile dysfunction, second-generation phosphodiesterase 5 inhibitor, for the treatment of male bo
Conclusion
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