Lopinavir CAS# 192725-17-0

Aluviran, Promotion Season Now in Store and Free Sample for Testing with Factory Price

• Chemical Name:Aluviran
• CAS No.:     192725-17-0
• Molecular Fomula: ：C37H48N4O5
• Molecular weight：628.81
• Appearance: white powder
• Sample：Available

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Description of Aluviran

A selective HIV protease inhibitor. An analogue of Ritonavir. Antiviral.

Basic Info of Aluviran

Basic Info
Properties
Safety Info
Basic Info

Properties

Safety Info

What is Aluviran?

• With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Lopinavir   which has developed particularly rapidly in recent years. Do you know about Lopinavir  ?
• The official answer：Lopinavir, chemically known as (2S)-N-[(2R,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazepam-1-yl)butyramide, is a new generation of HIV protease designed and improved by Abbott based on ritonavir It is a new generation of HIV protease inhibitor designed and improved by Abbott based on ritonavir. It can be used in biochemical experiments, synthetic experiments, and other tests.

What’s the application of Lopinavir?

• The oral bioavailability of Aluviran is poor due to the high expression of P-GP and MRP2-mediated efflux pump on the luminal surface of intestinal epithelial cells, the extensive metabolism of CYP3A4 enzymes in the liver, and the low water solubility of Aluviran itself (40 mg/mL). The efflux pump action is associated with the cellular excretion of foreign substances and toxic molecules, so the strategy to improve the bioavailability of Aluviran is focused on inhibiting the normal physiological function of the efflux pump, there is a risk of serious side effects to the organism. Ritonavir is not only a protease inhibitor but also a strong inhibitor of CYP450 enzymes (CYP3A4 is its isoenzyme). Using small doses of ritonavir to competitively bind CYP3A4 with Aluviran can slow down the metabolism of Aluviran, improve the bioavailability of Aluviran, and enhance clinical efficacy. Abbott had developed a combination formulation of Aluviran and ritonavir consisting of 1 unit dose of Aluviran and ¼ dose of ritonavir. The formulation was approved by the FDA for marketing in the United States in 2000 and China in 2007 under the trade name Kaletra and is primarily used clinically for the treatment of AIDS. UsesAluviran is an HIV protease inhibitor and antiretroviral drug. It is used for the treatment of HIV-1 infection in adults and pediatric patients over 6 months of age.

Conclusion

Sincere to the customer and in good faith of quality is our forever followed motto. It’s the basement to be a human and do business. We take all responsibility for our products and service sincerely. We are a company integrating R&D, production, and sales. The design, research, and development of pharmaceutical intermediates including more than 330 kinds of pharmaceutical intermediates such as Anti-infectives, Cardiovascular and Cerebrovascular Systems, Digestive System, Santi-tumor, Nervous System, Geriatric Drugs, and Gynecological Drugs. At the same time, we have more than 4,000 factories in strategic cooperation with nearly 50,000 chemical products, so we can provide you with a one-stop purchasing service, which greatly saves customers’ procurement costs and time.

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