Gliclazide CAS 21187-98-4
Ganciclovir sodium CAS 107910-75-8
13 5 月, 2021Vanillin CAS 121-33-5
1 4 月, 2021
Gliclazide Properties
| Category | Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug |
| Standard | Medical standard |
| Shelf life | 2 years |
| Storage | should be stored in a well-closed container at low temperature, keep away from moisture, heat and light. |
| Test Item | Standard: USP |
| Identification | IR spectrum similar to that of RS |
| HPLC retention time similar to that of RS | |
| Related substance | Total impurities: NMT0.3% |
| Single impurity: NMT0.1% | |
| Heavy metals | NMT 10ppm |
| Loss on drying | NMT0.5% |
| Residue on ignition | NMT0.1% |
| Assay | 98.5%-101.0% |
Gliclazide Application
liclazide is an oral antihyperglycemic agent used for the treatment of diabetes mellitus type II.
It belongs to the sulfonylurea class of insulin secretagogues, which stimulates β cells of the pancreas to release insulin.
Gliclazide binds to the β cell sulfonyl urea receptor (SUR1), further blocking the ATP sensitive potassium channels.
Therefore, the potassium efflux substantially decreases, causing depolarization of the β cells.
Then the voltage-dependent calcium channels in the β cell are open, resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules.
Recent studies have also shown that gliclazide can effectiveimprove anti-oxidant status and nitric oxide-mediated vasodilation in Type 2 diabetes and protect pancreatic beta-cells from damage by hydrogen peroxide.
Gliclazide Packaging and Shipping
Packaging:Packing: Net each in 25kg or 1000kg plastic woven bag, lined with PE bag.
Shipping:It can be according to the customer’s request
Gliclazide Storage
Room temperature