N-ETHYL-9ALPHA, Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Chemical Name: Bimatoprost
- CAS No.: 155206-00-1
- Molecular Fomula: ：C25H37NO4
- Molecular weight：415.57
- Appearance: White powder
- Sample：Available
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Description of N-ETHYL-9ALPHA
Bimatoprost (marketed in the US, Canada and Europe by Allergan, under the trade name Lumigan) is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. In December 2008, the indication to lengthen eyelashes was approved by the U.S. Food and Drug Administration (FDA); the cosmetic formulation of bimatoprost is sold as Latisse .
Basic Info of N-ETHYL-9ALPHA
Basic Info
Numbering system
Properties
Basic Info
| Chemical Name | bimatoprost |
| Synonyms | BiMatoprost HOUSE STANDARD;BiMapnost;Prostamide;17-Phenyl-tri-norprostaglandin F2α-ethyl amide;LUMIGAN;Expand |
| CAS No. | 155206-00-1 |
| Molecular Formula | C25H37NO4 |
| Molecular Weight | 415.56600 |
| PSA | 89.79000 |
| LogP | 3.53780 |
Numbering system
| MDL number | MFCD03411999 |
Properties
| Appearance & Physical State | crystalline solid |
| Density | 1.145 g/cm3 |
| Boiling Point | 629.8ºC at 760 mmHg |
| Flash Point | 334.7ºC |
| Refractive Index | 1.591 |
| Storage Condition | -20ºC |
| Vapor Pressure | 9.94E-17mmHg at 25°C |
What is Bimatoprost?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Bimatoprost which has developed particularly rapidly in recent years. Do you know about Bimatoprost ?
- The official answer：Bimatoprost is a prostaglandin drug that was first used to treat eye diseases such as glaucoma under the drug name Lumigan. However, during the treatment, patients unexpectedly noticed a significant increase in the diameter, length, and density of their eyelashes. Bimatoprost was then used in clinical trials for eyelash aesthetics, and its dramatic effect on eyelash thickening and density led directly to the launch of Lattice by Allergan, the company that manufactures Lumigan, which was approved by the FDA in December 2008 as a professional product for darkening and thickening eyelashes.
What’s the application of Bimatoprost?
- Olaparib is effective in Brca1;p53 breast tumors (50 mg/kg daily intraperitoneal injection), but not in HR-deficient Ecad;p53 breast tumors. olaparib has been used to treat BRCA mutated tumors such as ovarian, breast, and prostate cancers. prostate cancer. In addition, Olaparib inhibits ATM-deficient tumor cells selectively, suggesting that Olaparib may be a potential agent for the treatment of ATM-mutated lymphoma. UsesOlaparib is a PARP inhibitor that also acts on BRCA1 or BRCA2 mutations. Olaparib has little effect on end-anchor (polymerase)-1, with IC50 values greater than. Olaparib concentrations of 30-100 nM act on SW620 cells to inactivate PARP-1. Compared to BRCA1 and BRCA2 sufficient cell lines (Hs578T, MDA-MB-231, T47D), BRCA1-deficient cell lines (MDA-MB-463[1] and HCC1937) were overly sensitive to Olaparib Olaparib inhibited PARP and blocked base excision repair, resulting in KB2P cells being Olaparib to be strongly sensitive. The result leads to a shift from single-strand breaks to double-strand breaks during DNA replication and consequent activation of the BRCA2-dependent recombination pathway.
Conclusion
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