17-AAG , Promotion Season Now in Store and Free Sample for Testing with Factory Price
Chemical Name: 17-AAG
CAS No.: 75747-14-7
Molecular Fomula: C31H43N3O8
Molecular weight: 585.69
Appearance: solid
Sample: Available
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Description of Tanespimycin
Tanespimycin (17-N-allylamino-17-demethoxygeldanamycin, 17-AAG) is a derivative of the antibiotic geldanamycin that is being studied in the treatment of cancer, specific young patients with certain types of leukemia or solid tumors, especially kidney tumors.
It works by inhibiting Hsp90, which is expressed in those tumors.
It belongs to the family of drugs called antitumor antibiotics.
Basic Info of 17-AAG
Basic Info
Numbering system
Properties
Safety Info
Basic Info
|
Chemical Name |
tanespimycin |
|
CAS No. |
75747-14-7 |
|
Molecular Formula |
C31H43N3O8 |
|
Molecular Weight |
585.68800 |
|
PSA |
166.28000 |
|
LogP |
3.95760 |
Numbering system
|
UNII |
4GY0AVT3L4 |
Properties
|
Appearance & Physical State |
Dark purple solid |
|
Density |
1.21 |
|
Boiling Point |
797.8ºC at 760 mmHg |
|
Melting Point |
201-203ºC |
|
Flash Point |
436.3ºC |
|
Refractive Index |
1.566 |
|
Storage Condition |
-20ºC |
Safety Info
|
Safety Statements |
S22; S24/25; S36; S26 |
|
WGK Germany |
3 |
|
Risk Statements |
R36/37/38 |
|
Hazard Codes |
Xi |
What is Tanespimycin?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is 17-AAG which has developed particularly rapidly in recent years. Do you know about 17-AAG?
- The official answer: Tiratinib, known as Telatinib in English, has a molecular weight of 585.69 and is a stimulant.
What’s the application of Tanespimycin?
Tiratinib (17-AAG, CP127374, NSC-330507, KOS953) is a potent HSP90 inhibitor with an IC50 of 5 nM in cell-free assays and binds with Chemicalbook-derived HSP90 from tumour cells with 100-fold higher affinity than HSP90 from HSP90 from normal cells. Tiratinib (17-AAG) induced apoptosis, necrosis, autophagy and mitochondrial phagocytosis.
Conclusion
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