AcotiaMide CAS# 185106-16-5

formate salt, Promotion Season Now in Store and Free Sample for Testing with Factory Price

• Chemical Name:  AcotiaMide
• CAS No.:     185106-16-5
• Molecular Fomula: ：C21H30N4O5S
• Molecular weight：450.55
• Appearance: white powder
• Sample：Available

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Description of formate salt

• Acotiamide (YM-443, Z-338) is a drug approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia. It acts as an acetylcholinesterase inhibitor.

Basic Info of formate salt

Basic Info
Numbering system
Properties
Basic Info

Numbering system

Properties

What is AcotiaMide?

• With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is formate salt   which has developed particularly rapidly in recent years. Do you know about formate salt?
• The official answer：formate salt is a chemical with a density of 1.246±0.06 g/cm3 (Predicted) acidity coefficient (pKa) of 7.38±0.50 (Predicted), formate salt (Acofide, Z388) is a novel acetylcholinesterase (AChE) inhibitor with pro-gastric motility and fundus relaxation effects.

What’s the application of AcotiaMide?

• formate salt hydrochloride has the effect of promoting gastrointestinal motility and has a strong effect on postprandial gastric sinus motility in both rats and dogs. formate salt also has a significant effect on delayed gastric emptying in addition to increasing the contractile and motility potential of the stomach. In addition, it also has a significant effect on delayed gastric emptying and hypokinesis induced by colistin (an α2-adrenergic agonist) in dogs with FD. Postprandial enhancement of gastric sinus peristalsis induced by formate salt was completely inhibited by pretreatment with the muscarinic receptor bracketing agent atropine. In vivo experiments with anticholinesterase activity showed that administration of formate salt in the duodenum significantly enhanced acetylcholine-induced peristalsis, as was observed with the acetylcholinesterase inhibitor neostigmine. In addition, in vitro experiments found that formate salt significantly inhibited acetylcholinesterase activity in the gastric sinus of dogs when administered through the duodenum. The inhibition of acetylcholinesterase by formate salt was selective and reversible. Unlike itopride or mosapride, which have no affinity for dopamine D2 or serotonin 5-HT4 receptors, and without the side effects of cisapride on also the vasculature, formate salt did not affect myocardial single action potential timing or QT interval in anesthetized dogs. These results confirm that after administration through the digestive tract, formate salt inhibits acetylcholinesterase activity via a cholinergic route without affecting the QT interval, exerts pro-gastric motility, and has a high safety profile.

Conclusion

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