2-Amino-1,3-propanediol Typical Properties

2-Amino-1,3-propanediol Usage

1. This product is the main raw material of the synthetic drug iopamidol.

Application of 2-Amino-1,3-propanediol

1) Ceramide

Ceramide, one of the important derivatives of serinol, acts as a second messenger as the core molecule of sphingolipid metabolism. It can mediate apoptosis of malignant tumor cells and has tumor suppressing function [33]. Based on its tumor suppressing mechanism, American scientists used N-acylated serinol to synthesize a new type of ceramide, which can induce apoptosis in mitosis and is considered to be a potential drug for the treatment of cancer of the nervous system. . In the future, the development of ceramide will provide a new treatment strategy for the treatment of malignant tumors. In addition, ceramide is very easy to be absorbed by the skin and can promote the penetration of other nutrients. It is a highly effective moisturizer, especially 80% effective for moisturizing dry skin in the elderly. It is widely used in cosmetics. At the same time, ceramide also plays an important role in regulating the biological activity of the skin and the physiological function of the epidermis, so it is used in the treatment of skin diseases and the production of related drugs. For example: ceramide barrier cream can reduce dermatitis in children; oral ceramide preparation can improve the symptoms of patients with atopic dermatitis.

2) Sphingosine

Like ceramide, sphingosine has similar applications. It is not only the main component of topical drugs for skin diseases, but also a potential therapeutic factor used in antibacterial, fungal and anticancer drugs. In 2013, scientists isolated a novel sulfonated serinol derivative from tunicates. It is a p53-Hdm2 (p53 is a versatile tumor suppressor protein, the p53-Hdm2 complex formed by its combination with Hdm2 will make p53 lose its tumor suppressive effect), and it is expected to be applied in the future Cancer treatment. Multiple sclerosis is the most common demyelinating disease of the central nervous system in the population. Millions of people around the world are affected by this disease. Based on this, the first treatment for relapsed multiples was successfully developed in 2010 An oral drug for sclerosis-fingolimod. Fingolimod is a modulator of sphingosine 1-phosphate receptor, which exerts curative effects by reducing the number of self-invasive lymphocytes entering the central nervous system.

3) Other derivatives

In chemical production, serinol derivatives also exist as important intermediates. As early as 1947, the chiral compound (1R, 2R) -phenylserine has become a key intermediate in the industrial production of chloramphenicol. In addition, aromatic L-serinol derivatives are also important intermediates in the production of epinephrine and norepinephrine drugs.

2-Amino-1,3-propanediol Package

Packing: 25kg/barrel

2-Amino-1,3-propanediol Storage

Stored in cool dry ventilated place away from fire, heat, light, acids and food materials