TAK-438, Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Chemical Name: Vonoprazan Fumarate
- CAS No.: 1260141-27-2
- Molecular Fomula: ：C21H20FN3O6S
- Molecular weight：461.4634032
- Appearance: white powder
- Sample：Available
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Basic Info of TAK-438
Basic Info
Numbering system
Properties
Basic Info
| Chemical Name | Vonoprazan Fumarate |
| Synonyms | TAK-438;1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine,(E)-4-oxopent-2-enoic acid; |
| CAS No. | 1260141-27-2 |
| Molecular Formula | C21H20FN3O6S |
| Molecular Weight | 461.46300 |
| PSA | 146.97000 |
| LogP | 3.82910 |
Numbering system
| MDL number | MFCD18633280 |
Properties
| Soluble | DMSO > 10 mM |
What is Vonoprazan Fumarate?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Vonoprazan Fumarate which has developed particularly rapidly in recent years. Do you know about Vonoprazan Fumarate?
- The official answer：Vonoprazan fumarate (TAK-438, Vonoprazanfumarate) is a new oral anti gastric acid drug launched by Takeda Pharmaceuticals in cooperation with Otsuka Pharmaceuticals. [Registered Classification] Chemical Category 3.1 [Indications] For the treatment of erosive esophagitis, gastric ulcer, and duodenal ulcer. On February 28, 2014, Takeda Pharmaceutical submitted a New Drug Application (NDA) for vonoprazan (TAK-438) to the Japanese Ministry of Labor, Health and Welfare (MHLW). This NDA submission was based on good data from a Phase III clinical trial. Takeda Pharmaceutical has conducted several Phase III clinical trials in Japan to investigate the efficacy of TAK-438 for indications of erosive esophagitis, gastric ulcer, duodenal ulcer, and H. pylori eradication. Compared to the current pawn proton pump inhibitors (PPIs), Vonorazan (TAK-438) has shown better efficacy in clinical trials due to the absence of CYP2C19 metabolism: better efficacy than lansoprazole for the treatment of gastric ulcer/duodenal ulcer, reflux esophagitis, and H. pylori eradication, as well as good tolerability and safety.
What’s the application of Vonoprazan Fumarate?
- Treatment of duodenal ulcers, gastric ulcers, and reflux esophagitis, low-dose aspirin-induced gastric ulcers, or recurrent duodenal ulcers. Eradication of H. pylori and adjuvant treatment of the following diseases: gastric ulcer, duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura, early gastric cancer, H. pylori-infected gastritis.
Conclusion
Sincere to the customer and in good faith of quality is our forever followed motto. It’s the basement to be a human and do business. We take all responsibility for our products and service sincerely. We are a company integrating R&D, production, and sales. The design, research, and development of pharmaceutical intermediates including more than 330 kinds of pharmaceutical intermediates such as Anti-infectives, Cardiovascular and Cerebrovascular Systems, Digestive System, Santi-tumor, Nervous System, Geriatric Drugs, and Gynecological Drugs. At the same time, we have more than 4,000 factories in strategic cooperation with nearly 50,000 chemical products, so we can provide you with a one-stop purchasing service, which greatly saves customers’ procurement costs and time.
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