Dexbudesonide, Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Chemical Name: TriaMcinolone-d5
- CAS No.: 51372-29-3
- Molecular Fomula:C25H34O6
- Molecular weight：430.53
- Appearance: White powder
- Sample：Available
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Description of Dexbudesonide
Budesonide epimer R. Budesonide 22R epimer is more active than 22S epimer. Used as an antiinflammatory agent.
Basic Info of Dexbudesonide
Basic Info
Numbering system
Properties
Safety Info
Basic Info
| Chemical Name | 16a(R),17-(Butylidenebis(oxy))-11b,21-dihydroxypregna-1,4-diene-3,20-dione |
| Synonyms | arachidonic acid ethanolamide;N-arachidonoylethanolamide;5,8,11,14-Eicosatetraenoylethanolamide;N-Arachidonoyl-2-hydroxyethylamide;N-arachidonoyl ethanolamine;Expand |
| CAS No. | 51372-29-3 |
| Molecular Formula | C25H34O6 |
| Molecular Weight | 430.53400 |
| PSA | 93.06000 |
| LogP | 2.71680 |
Numbering system
| UNII | 2HI1006KPH |
Properties
| Appearance & Physical State | light beige solid |
| Density | 1.27 g/cm3 |
| Boiling Point | 599.7ºC at 760 mmHg |
| Melting Point | 194-199ºC |
| Flash Point | 201.8ºC |
| Storage Condition | -20ºC Freezer |
Safety Info
| HS Code | 2914509090 |
What is TriaMcinolone-d5?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is TriaMcinolone-d5 which has developed particularly rapidly in recent years. Do you know about TriaMcinolone-d5 ?
- The official answer：Budesonide is an inhaled glucocorticoid with a strong anti-allergic inflammatory effect, and its anti-allergic inflammatory effect is weaker than that of fluticasone propionate and mometasone furoate. The lipid solubility of budesonide is slightly poorer, but it has a stronger affinity for glucocorticoid receptors, which is mainly related to the special molecular configuration of budesonide, and the high hepatic first-pass metabolism effect of budesonide (about 90%), which significantly reduces the amount of drug entering the body circulation. Studies have shown that the airway anti-inflammatory strength of budesonide is 600 times that of hydrocodone and 2k0-30 times that of dexamethasone and that the local effect of inhaled budesonide is strong and less absorbed, so that inhalation of a small dose of budesonide can produce a strong local anti-allergic inflammatory effect on the airway and fewer side effects. Research data show that after the systemic absorption of budesonide, it is degraded by the liver for the first time about 85-90%, and the biological activity of its metabolites is low, so the local anti-inflammatory effect of this product is significantly stronger than the effect of its systemic glucocorticoids in a wide range of doses, that is, this product mainly works locally, and a small amount can play the same role in preventing asthma or allergic rhinitis as oral high-dose hormones, but the systemic side effects are significantly smaller than those of oral hormones. The side effects are significantly less than those of oral hormones.
What’s the application of TriaMcinolone-d5?
- This product is a glucocorticoid with a highly effective local anti-inflammatory effect. It enhances the stability of endothelial cells, smooth muscle cells, and lysosomal membranes, inhibits immune responses and reduces antibody synthesis, resulting in a decrease in the release and activity of allergy-active mediators such as histamine, and reduces the enzymatic processes stimulated by antigen-antibody binding, inhibits the synthesis and release of bronchoconstrictor substances and reduces the contractile response of the smooth muscle. Acute, subacute, and long-term toxicity studies have found that the systemic effects of this product, such as weight loss, lymphoid tissue, and adrenal cortex atrophy, are weaker or comparable to those of other glucocorticoids.
Conclusion
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