Tacrolimus , Promotion Season Now in Store and Free Sample for Testing with Factory Price
Chemical Name: Tacrolimus
CAS No.: 104987-11-3
Molecular Fomula: C44 H69 N O12
Molecular weight: 804.02
Appearance: White solid
Sample: Available
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Description of FK-506
- Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the body’s learned (or adaptive) immune response.
- Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura’s disease, and the skin condition vitiligo.
Chemically it is a 23-membered macrolide lactone that was first discovered in 1987 from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukuba
Basic Info of Tacrolimus
Basic Info
Numbering system
Properties
Safety Info
Basic Info
| Chemical Name | Tacrolimus |
| CAS No. | 104987-11-3 |
| Molecular Formula | C44H69NO12 |
| Molecular Weight | 804.01800 |
| PSA | 178.36000 |
| LogP | 4.57690 |
Numbering system
| PubChem number | 24724482 |
| RTECS number | KD4201200 |
Properties
| Appearance & Physical State | White or off-white crystalline powder |
| Density | 1.19 g/cm3 |
| Boiling Point | 871.7ºC at 760 mmHg |
| Melting Point | 113-115ºC |
| Flash Point | 481ºC |
| Refractive Index | 1.549 |
| Storage Condition | -20ºC |
| Vapor Pressure | 1.73E-35mmHg at 25°C |
Safety Info
| RTECS | KD4201200 |
| Safety Statements | S45-S36-S26 |
| WGK Germany | 3 |
| RIDADR | UN 2811 6 |
| Risk Statements | R25; R36/37/38 |
| Hazard Codes | Xi; T |
What is FK-506?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Tacrolimus which has developed particularly rapidly in recent years. Do you know about Tacrolimus?
- The official answer: Tacrolimus, also known as FK506, is a fermentation product isolated from Streptomyces spp. It is a macrolide antibiotic, a potent new immunosuppressive agent, mainly by inhibiting the release of interleukin-2 (IL-2) and fully suppressing T lymphocytes, which is 100 times stronger than cyclosporine (CSA). In recent years, it has been marketed in 14 countries, including Japan and the United States, as the first-line drug for liver and kidney transplantation.
What’s the application of FK-506?
Macrolide antibiotics. Immunosuppressants. The same mechanism of action as cyclosporine mainly inhibits the synthesis of interleukin-2. Used for rejection reactions in organ transplantation.
Conclusion
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