Silver sulfadiazine CAS 22199-08-2
Dimethyl sulfate CAS 77-78-1
22 9 月, 2020Potassium hydrogen phthalate CAS 877-24-7
22 9 月, 2020
Silver sulfadiazine Typical Properties
| Item | Specifications |
| Appearance | White to creamy-white,crystalline powder, odorless to having a
slight odor.ls stable in air,but turns yellow on exposure to light. |
| Solubility | Freely soluble in 30% ammonium solution;slightly soluble in
acetone; practically insoluble in alcohol, in chloroform,and in ether.Decomposes in moderately strong mineral acids. |
| Identification | A: Infrared Absorption<1 97> |
| B:The retention time of the major peak of the Samplesolution corresponds to that of the Standard solution, as obtained in the Assay. | |
| C: Chemical Identification Tests, Silver:Meets the requirements. | |
| Chroma | ≤ 0.05% |
| Loss on Drying | ≤ 0.5% |
| Limit of Nitrate | ≤ 0.1 |
| Organic Impurities | Sulfanilic acid ≤0.3% |
| Sulfaguanidine≤ 0.10% | |
| Sulfanilamide≤ 0.10% | |
| 2-Aminopyrimidine≤ 0.3% | |
| Acetylsulfadiazine≤≤0.2% | |
| Specified unidentified impurity(RRT 1.28)≤ 0.15% | |
| Individual unspecified impurity≤ 0.10% | |
| Total impurities≤ 0,5% | |
| Content of Silver | 29.3%-30.5% |
| Assay(on the dried basis) | 98.0~102% |
Silver sulfadiazine Usage
Used to treat infections of burn wounds
Silver sulfadiazine Packaging and Shipping
Packing: 25kg/drum
Silver sulfadiazine Pharmacological action
1. This product is a sulfa antibacterial drug, which has the dual effects of sulfadiazine and silver salt. It has antibacterial activity against most gram-positive and gram-negative bacteria, and has astringent effect, which can make the wound dry, scab and heal early.
2. When the product comes into contact with wound exudate, it is slowly metabolized, and part of the drug can be absorbed locally into the blood. Generally, the absorption is less than 1/10 of the dose, and the blood concentration of sulfadiazine can reach about 10-20mg/L. When the wound is wide and the dosage is large, the absorption increases and the blood concentration can be higher. Under normal circumstances, the absorption of silver in this product does not exceed 1% of its content. The product has poor penetration to necrotic tissue.