ROLIPRAM , Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Chemical Name: ROLIPRAM
CAS No.: 61413-54-5
Molecular Fomula: C16H21NO3
Molecular weight: 275.34
Appearance: White Powder
Sample: Available
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Description of ROLIPRAM
Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s. It served as a prototype molecule for several companies’ drug discovery and development efforts.:668ff Rolipram was discontinued after clinical trials showed that its therapeutic window was too narrow; it could not be dosed at high enough levels to be effective without causing significant gastrointestinal side effects.:668; Rolipram has several activities that make it a continuing focus for research. The etiology of many neurodegenerative diseases involves misfolded and clumped proteins which accumulate in the brain. Cells have a mechanism to dispose of such proteins called the proteasome.
Basic Info of ROLIPRAM
Basic Info
Numbering system
Properties
Safety Info
Basic Info
| Chemical Name | rolipram |
| CAS No. | 61413-54-5 |
| Molecular Formula | C16H21NO3 |
| Molecular Weight | 275.34300 |
| PSA | 47.56000 |
| LogP | 2.94890 |
Numbering system
| MDL number | MFCD00270906 |
Properties
| Appearance & Physical State | solid |
| Density | 1.155 g/cm3 |
| Boiling Point | 472.7ºC at 760 mmHg |
| Melting Point | 127-133ºC |
| Flash Point | 239.7ºC |
| Refractive Index | 1.552 |
| Storage Condition | 0-6ºC |
Safety Info
| Hazard Class | 6.1(b) |
| Safety Statements | S26; S36 |
| HS Code | 2933790090 |
| Packing Group | III |
| RIDADR | UN 3249 |
| Risk Statements | R36/37/38 |
| Hazard Codes | Xi |
What is SB95952?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is ROLIPRAM which has developed particularly rapidly in recent years. Do you know about ROLIPRAM?
- The official answer: Light yellow crystal. Melting point 118-120°C.
What’s the application of SB95952?
Selective inhibitor of PDE4, Rolipram (ZK-62711, SB 95952), inhibits the activity of immunopurified PDE4B and PDE4D with IC50 of 130 nM and 240 nM, respectively. has anti-inflammatory activity.
Conclusion
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