Hydroxychloroquine sulfate CAS# 747-36-4

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• Chemical Name:  Hydroxychloroquine sulfate
• CAS No.:     747-36-4
• Molecular Fomula: ：C18H28ClN3O5S
• Molecular weight：433.95
• Appearance:white powder
• Sample：Available

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Description of Plaquinol

An antimalarial; antirheumatic; lupus erythematosus suppressant.

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Properties

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What is Hydroxychloroquine sulfate?

• With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Hydroxychloroquine sulfate   which has developed particularly rapidly in recent years. Do you know about Hydroxychloroquine sulfate?
• The official answer：Hydroxychloroquine sulfate is an antimalarial drug that also has anti-inflammatory, immunomodulatory, and anticoagulant effects. Currently, hydroxychloroquine is mainly used clinically for the treatment of rheumatoid arthritis, juvenile chronic arthritis, discoid lupus erythematosus, and systemic lupus erythematosus, but the clinical onset of action is slow, often taking 2 to 4 months. The pharmacological effects of this drug are not well understood; it may be related to stabilization of lysosomal membranes, inhibition of prostaglandin formation, inhibition of polymorphonuclear cell chemotaxis and phagocytosis, possible interference with monocyte interleukin-1 formation, and inhibition of neutrophil superoxide release.

What’s the application of Hydroxychloroquine sulfate?

• Hydroxychloroquine sulfate has similar pharmacological effects, pharmacokinetics and in vivo metabolic processes as chloroquine. After oral administration, hydroxychloroquine is rapidly and almost completely absorbed. In one study, the mean plasma peak concentration after administration of a single dose of 400 mg of hydroxychloroquine to healthy volunteers ranged from 53-208 ng/ml, with a mean level of 105 ng/ml. The mean time to peak plasma concentration was 1.83 hours. Depending on the time after administration, the mean plasma elimination half-life varied as follows: 5.9, 26.1, and 299 hours at -10, 10-48, and 48-504 hours after peak plasma concentration, respectively. The parent compound and metabolites are widely distributed in the organism and elimination is mainly through the urine. In one study, 3% of the administered dose was observed at 24 hours.

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