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- Chemical Name: Heparin sodium
- CAS No.: 9041-08-1
- Molecular Fomula:C12H16NS2Na3
- Molecular weight：
- Appearance: White powder
- Sample：Available
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Basic Info of PORCINE
Basic Info
Numbering system
Basic Info
| Chemical Name | Heparin sodium |
| Synonyms | |
| CAS No. | 9041-08-1 |
| Molecular Formula | |
| Molecular Weight | 0.00000 |
| PSA | 0.00000 |
| LogP | 0.00000 |
Numbering system
| EINECS number | 618-546-9 |
What is Heparin sodium?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Heparin sodium which has developed particularly rapidly in recent years. Do you know about Heparin sodium ?
- The official answer：Heparin sodium is a white or off-white powder, odorless, moisture-attracting, easily soluble in water, insoluble in ethanol, acetone, and other organic solvents. It has a strong negative charge in an aqueous solution and can combine with some cations to form molecular complexes. Aqueous solution is more stable at pH 7, specific rotation D25 +47° (c = 1.5 in water) Storage conditions 2-8°C Solubility H2O: 50 mg/mL, clear, faintly yellow.
What’s the application of Heparin sodium?
- Heparin sodium is a mucopolysaccharide biochemical drug extracted from pig small intestine mucosa with strong anticoagulant activity. Mclean discovered this stranded mucopolysaccharide substance heparin from dog liver tissue when studying the coagulation mechanism. Brinks et al. proved that heparin has anticoagulant activity, and after heparin was used for the first time as an anticoagulant for clinical application, it has received attention from all over the world. Heparin has a strong anticoagulant It has been used in clinical practice for more than 60 years, but so far no product can completely replace it, so it is still one of the most important anticoagulants and antithrombotic biochemical drugs. It is used in the treatment of acute myocardial infarction, pathogenic hepatitis, and can increase the efficacy of hepatitis B when used in combination with RNA and chemotherapy. Low-molecular-weight heparin sodium has anti-coagulation factor Xa activity. Pharmacodynamic studies have shown that low-molecular-weight heparin sodium has an inhibitory effect on the formation of internal and external thrombosis and arterial and venous thrombosis, but has little effect on the coagulation and fibrinolytic system, and has little possibility of bleeding when it has an antithrombotic effect. Common heparin is a mixture containing a variety of aminoglycosides, which can delay or prevent blood coagulation both in vivo and in vitro. Its anticoagulant mechanism is complex and has effects on all aspects of coagulation. These include inhibiting the conversion of prothrombin to thrombin; inhibiting thrombin activity; preventing the conversion of fibrinogen to fibrin; and preventing platelet aggregation and destruction. Heparin can also lower blood lipids, lower LDL and VLDL, raise HDL, change blood viscosity, protect vascular endothelial cells, prevent atherosclerosis, promote blood flow, improve coronary circulation, and other effects. Heparin sodium should not be combined with coumarins, NSAIDs, dipyridamole, dextran, corticosteroids, diuretic acid, urokinase, etc., which may aggravate bleeding; there is a synergistic effect with methimazole and propylthiouracil; this product is contraindicated with ceftazidime, cefothiophene, erythromycin, azithromycin, erythromycin, vitamins, aminoglycoside antibiotics, polymyxin B, vancomycin, hydrocortisone, Chlorpromazine, and promethazine are contraindicated.
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