Epothilone B, Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Chemical Name: Epothilone B
- CAS No.: 152044-54-7
- Molecular Fomula: ： C27H41NO6S
- Molecular weight： 507.68
- Appearance: White Solid
- Sample：Available
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Description of Epothilone B
Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.
Basic Info of Ganciclovir sodium
Basic Info
Numbering system
Properties
Safety Info
Basic Info
| Chemical Name | heptadecane-5,9-dione |
| Synonyms | Epothilone B;EPO906;(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;GNF-PF-193;Epothilone B (EPO906,Patupilone);Expand |
| CAS No. | 152044-54-7 |
| Molecular Formula | C27H41NO6S |
| Molecular Weight | 507.68300 |
| PSA | 137.49000 |
| LogP | 4.47750 |
Numbering system
| UNII | UEC0H0URSE |
Properties
| Appearance & Physical State | White fine powder |
| Density | 1.596 g/cm3 |
| Boiling Point | 494.9ºC at 760 mmHg |
| Melting Point | 166-168ºC |
| Flash Point | 292.5ºC |
| Refractive Index | 1.597 |
Safety Info
| Safety Statements | S24/25 |
| HS Code | 2905430000 |
| WGK Germany | 3 |
What is Epothilone B?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Epothilone B which has developed particularly rapidly in recent years. Do you know about Epothilone B ?
- The official answer：Epothilone, a class of macrolides, was first reported in 1993 by G. Hö file et al. of the German National Center for Biotechnology (GBF). Epothilone can be isolated from the fermentation broth of a fibrous heap cyst strain of the mucilaginous suborder Epothilone A and B, which are the main components.
- Their paclitaxel-like microtubulin polymerization and inhibition of microtubule depolymerization activities make them a new generation of antimitotic drugs, whose mechanism of action is similar to that of paclitaxel-like drugs, which can bind to microtubulin to cause cancer cells to fail to undergo mitosis smoothly, and then cause apoptosis of cancer cells. Ebolimycin is superior to paclitaxel in terms of antitumor spectrum, antitumor activity, safety, water solubility, and synthesis method, and is expected to become a more effective antitumor drug than paclitaxel.
What’s the application of Epothilone B?
- (-)-Neomycin B is a microtubule (MT) stabilizing drug derived from the natural mucilage bacterium Sorangiumcellulosum, a macrolide antitumor factor. epub has similar biological properties to EPA. However, upon was 10-fold more potent than EPA in effectively combating P-glycoprotein expressing multidrug-resistant (MDR) cells (IC50=2nMforMDRCCRF-CEM/VBL100cells). (-)-Neomycin B is similar to paclitaxel and can replace paclitaxel in cell growth.epub caused cell cycle arrest (IC50=3.5 nM). Neomycin B is an organic synthesis intermediate and pharmaceutical intermediate and can be used in laboratory research and development processes and chemical and pharmaceutical synthesis
Conclusion
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