Dextran Sulfate Sodium Salt, Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Chemical Name: Dextran Sulfate Sodium Salt
- CAS No.: 9011-18-1
- Molecular Formula: (C6H7Na3O14S3)n
- Molecular weight:
- Appearance: White to off-white powder
- Sample: Available
Send Inquiry
Download Quotation
Basic Info of Dextran Sulfate Sodium Salt
Basic Info
Numbering system
Basic Info
| Chemical Name | Dextran sulfate sodium |
| Synonyms | |
| CAS No. | 9011-18-1 |
| Molecular Formula | |
| Molecular Weight | 0.00000 |
| PSA | 0.00000 |
| LogP | 0.00000 |
Numbering system
| EINECS number | 618-471-1 |
What is Dextran Sulfate Sodium Salt?
With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Dextran Sulfate Sodium Salt which has developed particularly rapidly in recent years. Do you know about Dextran Sulfate Sodium Salt?
The official answer: Glycolic anhydride ester (9011-18-1) properties: This product is a light yellow powder; it has moisture-attracting properties. It is soluble in water and insoluble in ethanol and ether. 6% aqueous solution is colorless or light yellow clear liquid with pH 5-7.5. This product started to be used as a plasma substitute and later used to lower blood lipids. It can improve the vitality of the fibrinolytic system, prevent the deposition of fibrin and anticoagulation; it can effectively improve the vitality of lipoproteins, promote the freeing of esterase into blood, decompose celiac particles and clarify blood lipids; reduce the content of total cholesterol in serum, release the affinity of β-lipoprotein and fibrin to the blood vessel wall; it can antagonize the effect of vitronectin and reduce the normal metabolism of the blood vessel wall.
What’s the application of Dextran Sulfate Sodium Salt?
It is used for hypolipidemic and anti-atherosclerotic drugs.
Production method:
Hydrolyze dextran with water, heat, and dissolve to 200g/L (20%), then add hydrochloric acid to make 0.3%-0.4%, hydrolyze at reflux for 3h, cool slightly, neutralize with 100g/L (10%) NaOH solution to pH6-6.5, get hydrolysis solution.
Cool, add ethanol up to 40%, leave at 30℃ for 24h, take the supernatant and concentrate under vacuum to 1/4 of the original volume, add ethanol up to 70%, leave for 4-6h, shake dry, collect the precipitate, and obtain micro-molecular dextran.
Viscosity (η)=0.03-0.04, yield about 60%.
Dextrose anhydride [HCl,NaOH] → [3h,pH6-6.5] hydrolysis solution [ethanol] → micro-molecular dextrose anhydride esterification was fed in the ratio of macro-molecular dextrose anhydride (m): pyridine (V): chlorosulfonic acid (V) = 1:6:1.48.
Take pyridine (or use formamide instead) into the reaction tank, add chlorosulfonic acid dropwise at 25℃ with stirring, heat to 45-65℃, put in macro-molecular dextrose anhydride powder, keep warm for 2.5-4h, let it stand and stratify, pour out the upper layer of pyridine, and get paste esterification product.
Micro-molecular dextran [pyridine, chlorosulfonic acid] → [45-65℃,2.5-4h] paste esterification (dextran ester pyridine trioxide complex salt) neutralization, drying the paste esterification stirring and cooling, adding an appropriate amount of water at about 30℃, neutralize with 400g/L (40%) NaOH solution to pH10-11, stand and stratify, add an appropriate amount of water and ethanol in the lower layer to make its mass concentration The lower layer was washed with water and ethanol to reach 455g/L (45.5%), then washed with stirring at 37℃ for 30min, left to stand, and the lower layer was washed twice by repeating the above operation.
Sodium glycolate solution was obtained. Add appropriate amount of water and activated carbon, decolorize at 50℃, press filtration, add an appropriate amount of water and ethanol to the filtrate, make ethanol reach 47.5%, heat preservation and stirring at 37℃ for 30min, let stand, separate the lower layer, then decant the lower layer with ethanol, shake dry, dry at 50℃, get sodium glycyrrhizinate.
The total yield was 54% for dextran. Paste esterification [water, NaOH] → [30℃,pH10-11] lower liquid [ethanol] → sodium glycyrrhizinate solution [water, activated carbon] → filtrate [ethanol] → [37℃,30min] Sodium glycyrrhizinate preparation made according to the requirements of the tablets of sodium glycyrrhizinate enteric-coated tablets sodium glycyrrhizinate → sodium glycyrrhizinate tablets.
Conclusion
Sincere to the customer and in good faith of quality is our forever followed motto. It’s the basement to be a human and do business. We take all responsibility for our products and service sincerely. We are a company integrating R&D, production, and sales. The design, research, and development of pharmaceutical intermediates including more than 330 kinds of pharmaceutical intermediates such as Anti-infectives, Cardiovascular and Cerebrovascular Systems, Digestive System, Santi-tumor, Nervous System, Geriatric Drugs, and Gynecological Drugs. At the same time, we have more than 4,000 factories in strategic cooperation with nearly 50,000 chemical products, so we can provide you with a one-stop purchasing service, which greatly saves customers’ procurement costs and time.
Keywords of Dextran Sulfate Sodium Salt
Dexnon, 9011-18-1, buy Dexnon, Dexnon supplier, purchase Dexnon, Dexnon cost, Dexnon manufacturer, order Dexnon, high purity Dextran Sulfate Sodium Salt