Clomifene CAS# 911-45-5

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• Chemical Name: Clomifene
• CAS No.: 911-45-5
• Molecular Formula: C26H28ClNO
• Molecular weight: 405.96
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• Sample: Available

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Description of Clomifene

Clomifene (INN) or clomiphene (USAN) (trademarked as Androxal, Clomid and Omifin, citrate salt Serophene) is a selective estrogen receptor modulator (SERM) of the triphenylethylene group that has become the most widely prescribed drug for ovulation induction to reverse anovulation or oligoovulation.

It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.

Basic Info of Clomifene

Basic Info
Numbering system
Properties
Basic Info

Numbering system

Properties

What is Clomifene?

With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Clomifene which has developed particularly rapidly in recent years. Do you know about Clomifene?

The official answer: Clomiphene is a chemical. The chemical name is N,N-diethyl-2-[4-(1,2-diphenyl-2-chlorovinyl)phenoxy]ethylamine, molecular formula is C26H28ClNO, molecular weight is 405.96000, density is 1.104g/cm3, boiling point is 509ºC at 760mmHg. clomiphene has a strong anti-estrogenic effect and weak estrogenic activity clinically It is mainly used for amenorrhea and menstrual disorders caused by contraceptives.

What’s the application of Clomifene?

Clomiphene is a non-steroidal compound with weak estrogenic activity in experimental animals and anti-estrogenic activity in humans, which stimulates ovulation. It has a strong anti-estrogenic effect and weak estrogenic activity. Low doses promote the secretion of gonadotropins from the anterior pituitary gland, thus inducing ovulation; high doses significantly inhibit the release of pituitary gonadotropins, while in men it has a spermatogenesis-promoting effect and is effective in oligospermia.

Pharmacokinetics:

Clomiphene is orally absorbed, metabolized in the liver, and slowly excreted in the bile. Both prodrug and metabolites are excreted in the feces. The biological t1/2 is 5 days and traces can be detected in the feces after 6 weeks of administration. The E-isomer is less readily absorbed and is eliminated more rapidly than the Z-isomer. In vivo cis-structured drugs have a delayed peak plasma drug concentration and slower elimination, with a 1:1 plasma concentration of cis and trans 2h after administration, and 6:1 after 24h

Conclusion

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