Brn 4765855, Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Chemical Name: BRETAZENIL
- CAS No.: 84379-13-5
- Molecular Fomula:C19H20BrN3O3
- Molecular weight：418.28
- Appearance: white solid
- Sample：Available
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Description of Brn 4765855
- Bretazenil (Ro16-6028) is an imidazopyrrolobenzodiazepine anxiolytic drug which is derived from the benzodiazepine family, and was invented in 1988. It is most closely related in structure to the benzodiazepine antagonist flumazenil, although its effects are somewhat different. It is classed as a high-potency benzodiazepine due to its high affinity binding to benzodiazepine binding sites where it acts as a partial agonist. Its profile as a partial agonist and preclinical trial data suggests that it may have a reduced adverse effect profile. In particular bretazenil has been proposed to cause a less strong development of tolerance and withdrawal syndrome. Bretazenil differs from traditional 1,4-benzodiazepines by being a partial agonist and because it binds to α1, α2, α3, α4, α5 and α6 subunit containing GABAA receptor benzodiazepine receptor complexes. 1,4-benzodiazepines bind only to α1, α2, α3 and α5 GABAA benzodiazepine receptor complexes.
Basic Info of Brn 4765855
Basic Info
Numbering system
Properties
Safety Info
Basic Info
| Chemical Name | Bretazenil |
| Synonyms | Ro-16-6028; |
| CAS No. | 84379-13-5 |
| Molecular Formula | C19H20BrN3O3 |
| Molecular Weight | 418.28400 |
| PSA | 64.43000 |
| LogP | 3.81870 |
Numbering system
| UNII | OSZ0E9DGOJ |
Properties
| Density | 1.56g/cm3 |
| Boiling Point | 594.3ºC at 760 mmHg |
| Flash Point | 313.2ºC |
| Refractive Index | 1.685 |
| Storage Condition | 2-8ºC |
Safety Info
| Safety Statements | S22; S24/25 |
What is BRETAZENIL?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is BRETAZENIL which has developed particularly rapidly in recent years. Do you know about BRETAZENIL ?
- The official answer：Brontacitinib is a benzodiazepine GABAA receptor partial agonist that was first developed by Roche as an anxiolytic drug. It was found that brontocinib could counteract the spasticity caused by pentamethylene tetrazolium. At antitussive doses (125-250 μg-kg-1), brontocinib was combined with pyridostigmine (100 μg-kg-1,im) and alprofen (4 mg-kg-1,im) to prevent sarin and soman poisoning. Brodifacoum has good anxiolytic activity at doses of 50-400μg-kg-1 and has little adverse effects on muscle weakness compared with Valium, so it has obvious advantages as one of the components for the protection of the central nervous system.
What’s the application of BRETAZENIL?
Brontacitinib is a chemical substance whose use is in various pharmaceutical intermediates.
Conclusion
Sincere to the customer and in good faith of quality is our forever followed motto. It’s the basement to be a human and do business. We take all responsibility for our products and service sincerely. We are a company integrating R&D, production, and sales. The design, research, and development of pharmaceutical intermediates including more than 330 kinds of pharmaceutical intermediates such as Anti-infectives, Cardiovascular and Cerebrovascular Systems, Digestive System, Santi-tumor, Nervous System, Geriatric Drugs, and Gynecological Drugs. At the same time, we have more than 4,000 factories in strategic cooperation with nearly 50,000 chemical products, so we can provide you with a one-stop purchasing service, which greatly saves customers’ procurement costs and time.
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