Adefovir CAS 106941-25-7
N-(Tert-butyl)hydroxylamine hydrochloride CAS 57497-39-9
9 6 月, 2020Hexylamine CAS 111-26-2
9 6 月, 2020
Adefovir Typical Properties
| Item | Specifications |
| Appearance | White or slight White powder |
| Identification | Maximum absorption at 261 nm |
| Loss on drying | ≤1.0% |
| Related substance | Any other impurity ≤0.5% |
| Total impurity ≤1.0% | |
| Assay | ≥98.0% |
| Brand name | Fousi chemical |
Adefovir Usage
- Adefovir is an acyclic nucleoside analogue of adenosine monophosphate, which is phosphorylated into an active metabolite, adefovir diphosphate, under the action of cellular kinases.
- Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) in the following two ways: one is to compete with the natural substrate deoxyadenosine triphosphate, and the other is to cause the extension of the DNA chain after integration into viral DNA.
- The inhibitory constant (Ki) of adefovir diphosphate on HBV DNA polymerase is 0.1 μM, but the inhibitory effect on human DNA polymerase α and γ is weak, with Ki values of 1.18 μM and 0.97 μM, respectively.
Adefovir Packaging and Shipping
Packing: 25kg/cardboard drum
Delivery: by ocean
Adefovir Storage
Store in a cool, ventilated warehouse, the storage temperature should not exceed 37℃ It should be stored separately from oxidants and food chemicals, and should not be mixed.