ARRY 142886, Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Chemical Name: Selumetinib
- CAS No.: 606143-52-6
- Molecular Fomula:C17H15BrClFN4O3
- Molecular weight：457.68
- Appearance: Beige powder.
- Sample：Available
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Description of ARRY 142886
Selumetinib (AZD6244) is a drug that was discovered by Array BioPharma and was licensed to AstraZeneca. It is being investigated for the treatment of various types of cancer, such as non-small cell lung cancer (NSCLC).
Basic Info of ARRY 142886
Basic Info
Numbering system
Properties
Safety Info
Basic Info
| Chemical Name | Selumetinib |
| Synonyms | 6-(4-bromo-2-chlorophenylamino)-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-3H-benzo[d]imidazole-5-carboxamide;5-[(4-BROMO-2-CHLOROPHENYL)AMINO]-4-FLUORO-N-(2-HYDROXYETHOXY)-1-METHYL-1H-BENZIMIDAZOLE-6-CARBOXAMIDE;6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide; |
| CAS No. | 606143-52-6 |
| Molecular Formula | C17H15BrClFN4O3 |
| Molecular Weight | 457.68100 |
| PSA | 88.41000 |
| LogP | 3.98950 |
Numbering system
| MDL number | MFCD11977472 |
Properties
| Appearance & Physical State | White or pale white solid. |
| Density | 1.69 |
| Storage Condition | Powder stores in -20ºC directly, which is effective for a period of 2 years. |
Safety Info
| HS Code | 2934999090 |
What is Selumetinib?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Selumetinib which has developed particularly rapidly in recent years. Do you know about Selumetinib ?
- The official answer：Smectinib, chemically known as 5-[(4-Bromo-2-chlorophenyl)amino-4-fluoro-N-(2-hydroxyethyl)-1-methyl-1H-benzimidazole-6-carboxamide, was developed by AstraZeneca in the UK for the treatment of advanced non-small-cell lung cancer (NSCLC). Its therapeutic mechanism is to inhibit the growth of various tumors, including melanoma with B-Raf-mutation and non-small cell lung cancer (NSCLC) with K-Ras mutation, mainly by regulating the level of MEK, a key protein kinase in the Ras-Raf-MEK-ERK pathway.
What’s the application of Selumetinib?
- The anti-cancer drug selumetinib (Selumetinib,1) was developed by AstraZeneca in the United Kingdom for the treatment of advanced non-small-cell lung cancer (NSCLC). Selumetinib inhibits the growth of a variety of tumors, including melanoma with B-Raf-mutations and non-small cell lung cancer (NSCLC) with K-Ras mutations, by regulating levels of MEK, a key protein kinase in the Ras-Raf-MEK-ERK pathway. It is mainly used for the treatment of cholangiocarcinoma, colorectal cancer, and NSCLC. Currently, sunitinib is in phase III clinical trial for the treatment of non-small cell lung cancer.
Conclusion
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