prostaglandin E1 CAS# 745-65-3

Prost-13-en-1-oic acid, Promotion Season Now in Store and Free Sample for Testing with Factory Price

• Chemical Name:  prostaglandin E1
• CAS No.:     745-65-3
• Molecular Fomula: ：C20H34O5
• Molecular weight：354.49
• Appearance:white powder
• Sample：Available

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Description of Prost-13-en-1-oic acid

Prostaglandin E1 (PGE1) is a prostaglandin.
The synthetic variant is known pharmaceutically as alprostadil. It is a drug used in the continuous treatment of erectile dysfunction and has vasodilatory properties. Misoprostol is another synthetic prostaglandin E1 analog used to prevent gastric ulcers when taken on a continuous basis, to treat missed miscarriage, to induce labor, and to induce abortion.

Basic Info of Prost-13-en-1-oic acid

Basic Info
Numbering system
Properties
Safety Info
Basic Info

Numbering system

Properties

Safety Info

What is prostaglandin E1?

• With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is prostaglandin E1   which has developed particularly rapidly in recent years. Do you know about prostaglandin E1?
• The official answer：Prostaglandin E1 (Prostaglandin E1) is also known as Prostadil, Pau D’Arco, Keshi, and Kevigel. Prostaglandin E1 is a biologically active substance widely present in the body, a member of the prostaglandin family, and a recognized endogenous physiologically active substance. Prostaglandin E1 acts directly on vascular smooth muscle to dilate blood vessels, increase blood flow and improve microcirculatory perfusion; and inhibits platelet aggregation and thromboxane A2 production, inhibits atherosclerosis, lipid plaque, and immune complex formation; dilates peripheral small vessels and coronary arteries, reduces peripheral vascular resistance and blood pressure, protects platelet cell membranes and prevents thrombosis; protects ischemic myocardium and reduces myocardial infarction area The t1/2 is 5~10min. 68% is excreted by the kidney after hepatic metabolism. Clinically used for coronary angina pectoris, myocardial infarction, pulmonary hypertension, chronic arterial occlusion, etc. This information was edited and compiled by Jianbin.

What’s the application of prostaglandin E1?

• Treatment of hepatitis hepatic sclerosis, cerebral infarction, diabetes mellitus, impotence, respiratory diseases. It has an antifibrovascular effect on CHILD A and B patients with non-severe hepatic impairment, especially CHILD A patients. Used for induction of labor, labor induction, renal insufficiency, treatment of mumps, pancreatitis, etc. Prostaglandin E1 for injection is mainly used in myocardial infarction, heart failure, thrombotic vasculitis, chronic arterial occlusive disease, central retinal vein thrombosis, for platelet protection in extracorporeal circulation, arteriography, revascularization surgery, etc. Use as a derivative of arachidonic acid. It can significantly inhibit and release platelet agglutination, improve blood microcirculation, and also act directly on vascular smooth muscle to dilate arterial vessels with a half-life of 5-10 minutes. It is used clinically for all types of angina pectoris, reducing the size of myocardial infarction, maintaining open arterial ducts in infants and children, somatic and pulmonary hypertension, peripheral vascular disease, and other forms of anticoagulation in extracorporeal circulation. Uses are indicated for myocardial infarction, heart failure, thrombotic vasculitis, chronic arterial occlusive disease, and central retinal vein thrombosis.

Conclusion

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