gr38032, Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Chemical Name: Ondansetron
- CAS No.: 99614-02-5
- Molecular Fomula: :C18H19N3O
- Molecular weight:293.36
- Appearance: White crystalline solid
- Sample:Available
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Description of gr38032
- Ondansetron, marketed under the brand name Zofran, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. It is also useful in gastroenteritis. It has little effect on vomiting caused by motion sickness. It can be given by mouth, by injection into a muscle or into a vein.
Common side effects include diarrhea, headache, sleepiness, and itchiness. Serious side effects include QT prolongation and severe allergic reaction. It appears to be safe during pregnancy but has not been well studied in this group. It is a serotonin 5-HT3 receptor antagonist. It does not have any effect on dopamine receptors or muscarinic receptors.
Ondansetron was first used medically in 1990. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication. The wholesale cost of the injectable form in the developing world is about 0.10 to 0.76 USD per dose. In the United States it costs about 1.37 USD per tablet.
Basic Info of gr38032
Basic Info
Numbering system
Properties
Safety Info
Basic Info
Chemical Name | 9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one |
Synonyms | ONDANSETRON HYDROCHLORIDE DIHYDRATE;9-METHYL-3-[(2-METHYL-1H-IMIDAZOLYL)METHYL]-1,2,3,9-TETRAHYDRO-4H-CARBAZOLE-4-ONE;ONDANSETRON-D5;ONDANSETRON HCL D6;9-METHYL-3-(2-METHYL-1H-IMIDAZOLYL)-METHYL-1,2,3,9-TETRAHYDRO-4H-CARBAZOLE-4-ONE;Expand |
CAS No. | 99614-02-5 |
Molecular Formula | C18H19N3O |
Molecular Weight | 293.36300 |
PSA | 39.82000 |
LogP | 3.12850 |
Numbering system
MDL number | MFCD00833882 |
Properties
Appearance & Physical State | White to yellow crystals |
Density | 1.27 g/cm3 |
Boiling Point | 546ºC at 760 mmHg |
Melting Point | 231 – 232ºC |
Flash Point | 284ºC |
Refractive Index | 1.691 |
Storage Condition | -20ºC |
Safety Info
RTECS | FE6375500 |
Safety Statements | S45 |
HS Code | 2933990090 |
WGK Germany | 3 |
RIDADR | UN 2811 6.1/PG 3 |
Risk Statements | R25 |
Hazard Codes | T; Xi |
What is Ondansetron?
- It is a 5-hydroxytryptamine (5-HT3) receptor antagonist, highly effective antiemetic, with high strength and high selectivity, controlling vomiting caused by stimulation of receptors in the small intestine and CTZ (chemoreceptor initiation center). It is used for the treatment of emesis caused by chemotherapy and radiotherapy especially the emetic effect caused by e.g. cisplatin, dacarbazine, azacitidine, and adriamycin. No external cone effect can be used simultaneously with acetylcholine, the antiemetic effect is better than meprobamate, Domperidone, phenothiazine, and butyl phenacyl benzene.
What’s the application of Ondansetron?
- It is a 5-hydroxytryptamine (5-HT3) receptor antagonist, highly effective antiemetic, with high strength and high selectivity, controlling vomiting caused by stimulation of receptors in the small intestine and CTZ (chemoreceptor initiation center). It is used for the treatment of emesis caused by chemotherapy and radiotherapy especially the emetic effect caused by e.g. cisplatin, dacarbazine, azacitidine, and adriamycin. No external cone effect can be used simultaneously with acetylcholine, the antiemetic effect is better than meprobamate, Domperidone, phenothiazine, and butyl phenacyl benzene.
Conclusion
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