Mecobalamin CAS# 13422-55-4

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• Chemical Name:  Mecobalamin
• CAS No.: 13422-55-4
• Molecular Fomula: ：C63H90CoN13O14P
• Molecular weight：1343.4
• Appearance:white powder
• Sample：Available

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Description of Algobaz

• Methylcobalamin (mecobalamin, MeCbl, or MeB12) is a cobalamin, a form of vitamin B12. It differs from cyanocobalamin in that the cyano at the cobalt is replaced with a methyl group. Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals. From the perspective of coordination chemistry, methylcobalamin is notable as a rare example of a compound that contains metal-alkyl bonds. Nickel-methyl intermediates have been proposed for the final step of methanogenesis.
  Methylcobalamin is equivalent physiologically to vitamin B12, and can be used to prevent or treat pathology arising from a lack of vitamin B12 (vitamin B12 deficiency), such as pernicious anemia.
  Methylcobalamin is also used in the treatment of peripheral neuropathy, diabetic neuropathy, and as a preliminary treatment for amyotrophic lateral sclerosis.
  Methylcobalamin is not sufficient as a singular source of vitamin B12. Hydroxocobalamin and cyanocobalamin can both be split by the body into methylcobalamin and adenosylcobalamin. Methylcobalamin on the other hand is not converted into adenosylcobalamin. Deficiency of adenosylcobalamin disturbs carbohydrate, fat and amino-acid metabolism, and hence interferes with the formation of myelin. Thereby it is important to treat vitamin B12 deficiency with hydroxocobalamin or cyanocobalamin or a combination of adenosylcobalamin and methylcobalamin.

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What is Mecobalamin?

• With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Mecobalamin   which has developed particularly rapidly in recent years. Do you know about Mecobalamin?
• The official answer：Methylcobalamin (Mecobalamin) is an endogenous vitamin B12, which is present in blood and myelin. Compared with vitamin B12, it has a good effect on neuronal conduction and can promote nucleic acid-protein-fat metabolism through methyl conversion reaction, and it acts as a coenzyme of methionine synthase, converts homocysteine to methionine, participates in the process of deoxyribonucleoside synthesis of thymine, and It promotes nucleic acid and protein synthesis, promotes intra-axonal transport and axonal regeneration and myelin formation, prevents axonal degeneration, and repairs damaged neural tissue. The peak blood concentration is reached 3 hours after oral administration, and its absorption is dose-dependent. It can be detected sequentially in blood, kidney, adrenal, pancreas, liver, and stomach tissues at higher concentrations, and in muscle, testis, and brain nerves at lower concentrations. The urinary excretion of a total of B12 8 hours after administration is 40% to 80% of the excretion 24 hours after dosing.

What’s the application of Mecobalamin?

• It is used for the treatment of neurological disorders, relief of pain and numbness, quick relief of neuralgia, improvement of pain caused by cervical spondylosis, treatment of sudden deafness, and other uses methylcobalamin is an endogenous coenzyme B12 that participates in the one-carbon unit cycle and plays an important role in the transmethylation reaction for the synthesis of methionine from homocysteine.

Conclusion

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