Epothilone D， Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Chemical Name: Epothilone D
- CAS No.: 189453-10-9
- Molecular Fomula:C27H41NO5S
- Molecular weight:491.68
- Appearance:white powder
- Sample: Available
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Description of Epothilone D
Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells’ microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.
Basic Info of Epothilone D
Basic Info
Numbering system
Basic Info
| Chemical Name | |
| Synonyms | Epo A;desoxyepothilone B;epithilone A;Epothilones;Expand |
| CAS No. | 189453-10-9 |
| Molecular Formula | C26H39NO5S |
| Molecular Weight | 477.65700 |
| PSA | 124.96000 |
| LogP | 4.87620 |
Numbering system
| UNII | T0358E0YUF |
What is Epothilone D ?
With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is it which has developed particularly rapidly in recent years. Do you know about it?
The official answer:It is a class of macrolides first reported in 1993 by G. Hö le et al. of the German National Centre for Biotechnology (GBF). Epothilone can be isolated from the fermentation broth of a strain of the mucilaginous suborder Clostridium fibrillar, the main components of which are Epothilone A and B.
What’s the application of Epothilone D ？
The mechanism of action is similar to that of paclitaxel, in that it binds to microtubule proteins and prevents cancer cells from undergoing mitosis, thereby causing apoptosis. it is superior to paclitaxel in terms of antitumor spectrum, antitumor activity, safety, water solubility, and synthesis method, and is expected to become a more effective antitumor drug than paclitaxel.
It have broad-spectrum anti-tumor activity and are effective against human tumors such as breast, prostate, lung, and colon cancers. The IC50 for it is in the nanomolar range.
Conclusion
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