Englenet Impurity 18, Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Chemical Name: Englenet Impurity 18
- CAS No.: 68-04-2
- Molecular Formula: C17H14ClIO3
- Molecular weight: 428.65
- Appearance: White to off-white crystalline powder
- Sample: Available
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Basic Info of Englenet Impurity 18
Basic Info
Numbering system
Properties
Basic Info
Chemical Name | Methanone, (2-chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]- |
Synonyms | Empagliflozin intermediate;(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone;(S)-(2-Chloro-5-iodophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)methanone; |
CAS No. | 915095-87-3 |
Molecular Formula | C17H14ClIO3 |
Molecular Weight | 428.64900 |
PSA | 35.53000 |
LogP | 4.34330 |
Numbering system
EINECS number | 619-598-5 |
Properties
Density | 1.639±0.06 g/cm3 (20 °C, 760 mmHg) |
Boiling Point | 525.9±50.0 °C (760 mmHg) |
What is Englenet Impurity 18?
With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Englenet Impurity 18 which has developed particularly rapidly in recent years. Do you know about Englenet Impurity 18?
The official answer: (2-chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone belongs to the ketone group of organic compounds and is a pharmaceutical intermediate for the preparation of C-aryl glucoside SGLT2 inhibitors with the following general formula. It is an intermediate of emphasizing, a potent and selective SGLT-2 inhibitor that improves glycemic control syndrome in diabetic rats.
What’s the application of Englenet Impurity 18?
(2-chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone belongs to the group of ketone organoids and can be used to prepare SGLT2 inhibitors of C-aryl glucosides with the following general formula.
SGLT2 is the major Na+/glucose co-transport protein in the epithelium of the S1 segment of the proximal tubule and is responsible for 90% of glucose reabsorption in the kidney.
SGLT2 inhibitors inhibit renal glucose reabsorption and allow diabetic patients to achieve levels with normal plasma glucose through urinary glucose excretion, thereby increasing insulin sensitivity and delaying the development of diabetic complications.
It can be used to prepare C-aryl glucoside SGLT2 inhibitors with the following general formula.
It is an intermediate of Empalizine, a potent and selective SGLT-2 inhibitor that improves glycemic control syndrome in diabetic rats.
Conclusion
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Keywords of Englenet Impurity 18
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