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- Chemical Name: Denosumab
- CAS No.: 615258-40-7
- Molecular Fomula:C17H15BrClFN4O3
- Molecular weight：
- Appearance: whtie powder.
- Sample：Available
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Basic Info of D03684
Basic Info
Numbering system
Basic Info
| Chemical Name | Denosumab |
| Synonyms | |
| CAS No. | 615258-40-7 |
| Molecular Formula | |
| Molecular Weight | 0.00000 |
| PSA | 0.00000 |
| LogP | 0.00000 |
Numbering system
| UNII | 4EQZ6YO2HI |
What is Denosumab?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Denosumab which has developed particularly rapidly in recent years. Do you know about Denosumab ?
- The official answer：Denosumab is the first monoclonal antibody approved to specifically target the RANK ligand, a transmembrane or soluble protein necessary for osteoblasts to maintain their structure, function, and survival
What’s the application of Denosumab ?
- Human RANKL mRNA is mainly found in bone, bone marrow, and lymphoid tissues, and its main roles in bone are to stimulate osteoclast differentiation and activity and to inhibit osteoclast apoptosis. Osteoclasts are responsible for bone resorption, and the presence of low levels of macrophage colony-stimulating factor and RANKL is necessary for the differentiation of osteoclast precursors into mature osteoclasts. Denosumab has a high affinity with RANKL, prevents RANK ligands from activating RANK on the surface of osteoclasts, inhibits osteoclast activation and development, reduces bone resorption, increases bone density and bone strength in both cortical bone and bone trabeculae, promotes bone reconstruction, and reduces the incidence of vertebral, nonvertebral and hip fractures in postmenopausal women with osteoporosis. The effect of denosumab on bone reconstruction can be assessed by measuring several bone renewal markers, such as N-terminal peptide, a marker of bone resorption, and bone-specific alkaline phosphatase, a marker of bone formation. In phase, I clinical study in healthy postmenopausal women, a dose-dependent decrease in NTX levels in morning urine was observed as soon as d2 after administration, which lasted up to 6 months, with a maximum decrease of 84% compared to baseline. This effect is reversible, and when serum denosumab levels disappear, NTX levels are seen to rise again, reflecting the reversibility of its effect on bone reconstruction. These effects will continue for a new cycle with continued treatment
Conclusion
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