Afatinib, Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Chemical Name: Afatinib
- CAS No.: 850140-72-6
- Molecular Fomula: C24H25ClFN5O3
- Molecular weight:485.94
- Appearance: Yellow powder
- Sample: Available
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Description of Afatinib CAS# 850140-72-6
It (INN; trade name Gilotrif in the US and Giotrif in Europe, previously Tomtovok and Tovok) is a drug approved in United States, Europe, Taiwan, Mexico, Chile and Japan as well as other countries for the first-line treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an irreversible covalent inhibitor of the receptor tyrosine kinases epidermal growth factor receptor (EGFR) and erbB-2 (HER2).
Basic Info of Afatinib CAS# 850140-72-6
Basic Info
Numbering system
Properties
Basic Info
| Chemical Name | |
| Synonyms | BIBW 2992;2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-;(E)-Tovok,BIBW;Tovok;Afatinib freebase;Expand |
| CAS No. | 850140-72-6 |
| Molecular Formula | C24H25ClFN5O3 |
| Molecular Weight | 485.93800 |
| PSA | 88.61000 |
| LogP | 4.53590 |
Numbering system
| UNII | 41UD74L59M |
Properties
| Appearance & Physical State | Off-White Solid |
| Melting Point | 100 – 102 °C |
What is Afatinib CAS# 850140-72-6?
With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is it which has developed particularly rapidly in recent years. Do you know about it?
The official answer:It is a potent, irreversible dual inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinases. It is indicated for the treatment of 1 locally advanced or metastatic non-small cell lung cancer (NSCLC) with an epidermal growth factor receptor (EGFR) sensitive mutation,
What’s the application of Afatinib CAS# 850140-72-6?
Like lapatinib and neratinib, afatinib is a protein kinase inhibitor that also irreversibly inhibits the human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases. Afatinib is not only useful against EGFR mutations targeted by first-generation tyrosine kinase inhibitors (TKI) such as erlotinib or geochemical bookfetinib, but also against less common mutations that are resistant to these drugs. However, it has no activity against T790M mutations that normally require third-generation drugs such as axitinib. Because it has additional activity against Her2, it is being investigated against breast cancer as well as other EGFR and Her2-driven cancers.
Conclusion
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