Tauroursodeoxycholic acid CAS# 14605-22-2

ursodeoxycholyltaurine, Promotion Season Now in Store and Free Sample for Testing with Factory Price

• Chemical Name:  Tauroursodeoxycholic acid
• CAS No.:     14605-22-2
• Molecular Fomula: ： C26H45NO6S
• Molecular weight：499.7
• Appearance: Colorless liquid
• Sample：Available

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Description of ursodeoxycholyltaurine

• Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid. It is the taurine conjugate form of ursodeoxycholic acid (UDCA). Humans are found to have trace amounts of TUDCA. However, bears contain large amounts of TUDCA in their bile; UDCA and conjugates comprise about 47% of the bile in American black bears and up to 76% in Asiatic bears. TUDCA has been used in ancient Asian pharmacopoeias for its supposed beneficial effects. UDCA is produced in several countries for the treatment of gallstones and liver cirrhosis. It is not approved by the Food and Drug Administration, in the U.S. while UDCA is approved in the United States for the treatment of primary biliary cirrhosis Ongoing research is finding TUDCA has diminishing apoptotic effects, helping with cardiac function, Huntington’s disease, Parkinson’s Disease, and stroke. Recently, TUDCA has been found to have protective effects in the eye, especially concerning retinal degenerative disorders.

Basic Info of ursodeoxycholyltaurine

Basic Info
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Properties
Safety Info
Basic Info

Numbering system

Properties

Safety Info

What is Tauroursodeoxycholic acid ?

• With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Tauroursodeoxycholic acid   which has developed particularly rapidly in recent years. Do you know about Tauroursodeoxycholic acid  ?
• The official answer：Tauroursodeoxycholic acid is the main active ingredient of bear bile and the main component of synthetic bear bile, which is widely present in the bile of humans and many animals as a bound bile acid with various physiological and pharmacological effects. It is mainly used in steroidal gallbladder stones, biliary cirrhosis, bile reflux gastritis, autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), chronic hepatitis (hepatitis B, C, etc.), alcoholic fatty liver, non-alcoholic fatty liver, drug-related liver damage, prevention and treatment of complications before and after liver transplantation, etc.

What’s the application of Tauroursodeoxycholic acid ?

• Sodium taurodeoxycholate, also known as taurodeoxycholic acid and taurodeoxycholic acid, chemically known as 3α,7β dihydroxycholanoyl-N-taurine, is mainly found in the bile of black bears and is the iconic active ingredient in bear bile. It has antispasmodic, anticonvulsant, anti-inflammatory, and gallstone dissolving effects. The modern synthetic drug taurine deoxycholic acid is a combined bile acid made by condensation between the cobalt group of ursodeoxycholic acid and the amino group of taurine. Ursodeoxycholic acid capsules have been marketed abroad and were approved for sale in China as imported drugs in 2007. They are mainly used clinically for the treatment of gallbladder cholesterol stones, primary sclerosing cholangitis, primary biliary cirrhosis, and chronic viral hepatitis C. At present, there is no drug registration for taurodeoxycholic acid API and its preparation in China. Sodium taurodeoxycholate is a natural bile acid isolated from bear bile, which is a chemical agent, combined with taurine in bile in the body, is a hydrophilic bile acid, and is a cholesterol stone dissolving agent. It can reduce the secretion of cholesterol by the liver, lower the saturation of cholesterol in bile, promote the secretion of bile acids, increase the solubility of cholesterol in bile, and dissolve cholesterol stones or prevent the formation of stones. It can increase the secretion of bile and relax the sphincter of the bile duct opening to produce a bile-boosting effect, which is conducive to the discharge of stones. This product cannot dissolve other types of gallstones. It is indicated for the treatment of cholesterol stones, hyperlipidemia, disorders of bile secretion, primary biliary cirrhosis, chronic hepatitis, bile reflux gastritis, and prevention of acute rejection and reaction to liver transplantation. The lithophytic effect of this product is slightly weaker than that of goose deoxycholic acid. The above information is edited and compiled by Andy.

Conclusion

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