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- Chemical Name: Vorinostat
- CAS No.: 149647-78-9
- Molecular Fomula: ：C14H20N2O3
- Molecular weight：264.32
- Appearance: white powder
- Sample：Available
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Description of Zolinza
- Vorinostat (rINN) also known as suberanilohydroxamic acid (suberoyl+anilide+hydroxamic acid abbreviated as SAHA) is a member of a larger class of compounds that inhibit histone deacetylases (HDAC). Histone deacetylase inhibitors (HDI) have a broad spectrum of epigenetic activities.
Vorinostat is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL) when the disease persists, gets worse, or comes back during or after treatment with other medicines. The compound was developed by Columbia University chemist Ronald Breslow and Memorial Sloan-Kettering researcher Paul Marks.
Basic Info of Zolinza
Basic Info
Numbering system
Properties
Safety Info
Basic Info
| Chemical Name | vorinostat |
| Synonyms | Suberoylanilidehydroxamic Acid;N-Hydroxy-N’-phenyloctanediamide;Vorinostat/SAHA;Suberoylanilide Hydroxamic Acid; |
| CAS No. | 149647-78-9 |
| Molecular Formula | C14H20N2O3 |
| Molecular Weight | 264.32000 |
| PSA | 78.43000 |
| LogP | 2.93500 |
Numbering system
| MDL number | MFCD00945317 |
Properties
| Appearance & Physical State | White Crystalline Solid |
| Density | 1.174 g/cm3 |
| Melting Point | 161-162ºC |
| Refractive Index | 1.566 |
Safety Info
| RTECS | SJ7453000 |
| Safety Statements | S53; S45; S24/25; S22; S36 |
| HS Code | 29349990 |
| WGK Germany | 3 |
| RIDADR | UN 2265 3/PG 3 |
| Risk Statements | R61; R20/21; R36; R36/37/38; R20/21/22 |
| Hazard Codes | T; Xn |
| Signal Word | Danger |
| Caution Statement | P201; P281; P308 + P313 |
| Symbol | GHS08 |
| Hazard Declaration | H341; H360 |
What is Vorinostat?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Vorinostat which has developed particularly rapidly in recent years. Do you know about Vorinostat?
- The official answer：Vorinostat is a group of protein deacetylase (HDAC) inhibitors. It can act by inducing cell differentiation, blocking the cell cycle, and inducing cellular regulation. Treatment of cutaneous T-cell lymphoma (CTCL, a type of non-Hodgkin’s lymphoma) that exacerbates, persists, and relapses, or fails after treatment with two systemic agents.CTCL is a leukocyte-type T-cell carcinoma that affects the skin.
What’s the application of Vorinostat?
Vorinostat is a novel molecularly targeted antitumor drug that causes cell cycle arrest and/or apoptosis by inhibiting histone deacetylase (HDAC). It is the first HDAC inhibitor approved by the FDA for the treatment of cutaneous T-cell lymphoma (CTCL) with significant skin invasion that has progressed, become resistant, or relapsed after two systemic regimens.
Conclusion
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